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This outer layer is divided into two further layers: The syncytiotrophoblast is a multinucleated continuous cell layer that covers the surface of the placenta. It forms as a result of differentiation and fusion inn the underlying cytotrophoblast cells, a process that soje throughout placental development. The syncytiotrophoblast otherwise known as syncytiumthereby contributes to the barrier function of the placenta. The placenta grows throughout pregnancy. Development of the maternal blood supply to the placenta is complete by the end of the first trimester of pregnancy week 14 DM Placental circulation[ edit ] Maternal blood fills the intervillous spacenutrients, water, and gases are actively and passively exchanged, then deoxygenated blood is displaced by the next maternal pulse.

Study Finds Zika Virus Replicates and Persists in Fetal Brains and Placentas Maternal placental circulation[ edit ] In preparation for implantation of the blastocyst, the uterine endometrium undergoes "decidualisation". Spiral arteries in decidua are remodeled so that they become less convoluted and their diameter is increased. The increased diameter Lloking straighter flow path both act to increase maternal blood flow to the Lookimg. There is relatively high pressure as pacetas maternal blood fills intervillous space through these spiral arteries bathes the fetal villi in blood, allowing an exchange of gases to Looking for some nsa in placetas place.

In humans and other hemochorial placentals, the maternal blood comes into direct contact with the Loking chorion Looking for some nsa in placetas, though no fluid is exchanged. As the pressure decreases between pulsesthe deoxygenated blood flows back through the endometrial veins. This begins at day 5 - day 12 [11] Further information: Fetal circulation Deoxygenated fetal blood passes through umbilical arteries to the placenta. At the junction of umbilical cord and placenta, the umbilical arteries branch radially to form chorionic arteries. Chorionic arteries, in turn, branch into cotyledon arteries. In the villi, these vessels eventually branch to form an extensive arterio-capillary-venous system, bringing the fetal blood extremely close to the maternal blood; but no intermingling of fetal and maternal blood occurs "placental barrier".

This may contribute to pre-eclampsia and other pregnancy complications. Most of the women were U. The eight infants with microcephaly who died were from Brazil and Colombia. Mothers of all the infants with fatal microcephaly and all of the women with positive test results contracted Zika virus during their first trimester of pregnancy. All of these women had Zika infection during their third trimester of pregnancy, but the babies who were tested for Zika after birth tested negative. These findings further confirm that Zika virus infection during the first trimester of pregnancy poses more danger for pregnancy and fetal development than infection contracted during the third trimester.

The molecular tests used in this study can show evidence of Zika virus in tissues long after the virus would be undetectable by blood tests, which typically can only be used during the 12 weeks following infection. CDC continues to recommend that pregnant women not travel to areas with Zika.




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